Antonina Dolgorukova
Hello, I'm Tonia.
I’m a biostatistician and data scientist with an M.D. and a background in experimental neuropharmacology. I develop statistical analyses, data-validation pipelines, and automated reporting for clinical trials, and build machine-learning models for biological data, from protein-function prediction and single-cell perturbations to animal behavior. Beyond biomedical applications, I also work on algorithmic problems in scientific computing and autonomous navigation.
How I got here
neuropharmacology & psychopharmacology
June 2016 – April 2022: Pavlov University, Valdman Institute of Pharmacology
Experimental pharmacology and therapy of pain and behavioral pharmacology.
Featured publications
- TAAR1 / nicotine, Frontiers in Pharmacology, 2018
- Metoclopramide and trigeminovascular nociception, Neuroscience, 2020
- Piezo1 / Yoda1 in the trigeminovascular system, Experimental Neurology, 2021
R-Pharm
May 2022 – Present: R-Pharm
Biostatistics for clinical development.
Featured outputs
- Olokizumab pharmacokinetics in COVID-19, Pharmacy & Pharmacology, 2022
- Olokizumab and mortality in hospitalized COVID-19, Infectious Diseases: News, Opinions, Training, 2022
- Generic nirmatrelvir bioequivalence, Pharmacy & Pharmacology, 2023
- Abbreviator, medical-document abbreviation management and audit tool
- ClinicalSampleSizePlanner, Shiny app for clinical-trial sample-size calculation
December 2024: CayleyPy project
Collaborative scientific ML project on computation and pathfinding on Cayley and Schreier coset graphs.
Featured research outputs
- CayleyPy RL, Advances in Theoretical and Mathematical Physics, 2026
- CayleyPy Growth, arXiv, 2025; presented at the NeurIPS 2025 MATH-AI Workshop
- MLPermutationSolver, my CayleyPy spin-off
May 2026: Robotics project
Studying SLAM algorithms for home robot navigation.
General Medicine
June 2018: Diploma in General Medicine
Pavlov First Saint Petersburg State Medical University
December 2023: CAFA 5 Protein Function Prediction on Kaggle
Large-scale multi-label prediction of protein functions.
13th of 1,625 teams (top 0.8%)
December 2023: Open Problems - Single-Cell Perturbations on Kaggle
Multi-output regression of gene-expression responses across cell types.
13th of 1,097 teams (top 1.2%)
Judges' Prize
July 2024: NeurIPS 2024 - Predict New Medicines with BELKA on Kaggle
Large-scale binary classification of compound-protein binding.
13th of 1,950 teams (top 0.7%)
Best student team solution
December 2025: MABe Challenge - Social Action Recognition in Mice on Kaggle
Mouse behavior classification from pose keypoint time series.
12th of 1,412 teams (top 0.8%)
June 2026: CAFA 6 Protein Function Prediction on Kaggle
Large-scale multi-label prediction of protein functions.
11th of 2,259 teams (top 0.5%, Solo)
Featured projects
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Python
MLPermutationSolver
GPU-accelerated PyTorch implementation of ML-guided beam search for permutation sorting; a spin-off from the CayleyPy research project.
-
Python
Abbreviator
Django app for managing and auditing abbreviations in .docx files; uses a fine-tuned Llama 3.2 model for medical-context suggestions.
-
R
ClinicalSampleSizePlanner
Shiny app for clinical trial sample size calculation (currently bioequivalence; extensible to other designs).
Core tools
Peer-reviewed journal articles
- CayleyPy RL: Pathfinding and reinforcement learning on Cayley graphs. Advances in Theoretical and Mathematical Physics, 2026.
- Meta-analysis of the effects of anti-migraine therapeutics in the rat trigeminovascular nociception model as a tool for design optimization. European Journal of Neuroscience, 2023.
- Bioequivalence study of generic nirmatrelvir in healthy volunteers. Pharmacy & Pharmacology, 2023.
- Characteristics of olokizumab pharmacokinetics in patients with novel coronavirus infection COVID-19. Pharmacy & Pharmacology, 2022.
- Olokizumab reduces the risks of death in hospitalized patients with moderate and severe COVID-19. Infectious Diseases: News, Opinions, Training, 2022.
- The implementation of transcranial Doppler ultrasonography for preclinical study of migraine. Canadian Journal of Physiology and Pharmacology, 2022.
- Electrophysiological model of trigeminovascular nociception as a tool for experimental study of migraine pharmacotherapy. Russian Journal of Pain, 2021.
- A systematic review and meta-analysis of cannabis-based medicines, cannabinoids and endocannabinoid system modulators tested for antinociceptive effects in animal models. Pain, 2021.
- Differential effects of the Piezo1 agonist Yoda1 in the trigeminovascular system. Experimental Neurology, 2021.
- The influence of metoclopramide on trigeminovascular nociception. Neuroscience, 2020.
- The action of TAAR1 agonist RO5263397 on executive functions in rats. Cellular and Molecular Neurobiology, 2020.
- Activation of trace amine-associated receptor 1 attenuates schedule-induced polydipsia in rats. Neuropharmacology, 2019.
- Trace Amine-Associated Receptor 1 modulates the locomotor and sensitization effects of nicotine. Frontiers in Pharmacology, 2018.
- Possible approaches to CYP2C9-guided prescription of sulfonylureas in Russia. Pharmacogenomics, 2016.
Preprints and workshop papers
- Advances in Protein Function Prediction from the Fifth CAFA Challenge. bioRxiv, 2026.
- CayleyPy Growth: Efficient growth computations and hundreds of new conjectures on Cayley graphs. arXiv, 2025; presented at the NeurIPS 2025 MATH-AI Workshop.
- ResearchArena-CayleyBench: RL/LLM Benchmark challenges which can advance mathematical research. AAAI 2026 Workshop on AI for Scientific Research.